Mestrado em Computação Gráfica

InforAbERTA 2018 - VIII Jornadas de Informática da Universidade Aberta, organizadas por Leonel Morgado, Nuno Sousa, Bruno Sousa e Arnaldo Santos, no âmbito da SIFT do DCET.Apresentação no InforAberta 2018 do mestrado em computação gráfica cuja primeira edição se inicia em 2018, oferecido conjuntamente pela Universidade Aberta, Universidade do Porto e Universidade de Coimbra.info:eu-repo/semantics/draf

Concomitant pulmonary embolism and aortic dissection: approach to anticoagulation

Os autores descrevem um caso de uma doente admitida após episódio pré-sincopal associado a precordialgia e cujo ecocardiograma sumário feito no Servic¸o de Urgência demonstrou alterac¸ões compatíveis com tromboembolismo pulmonar, tendo a doente sido submetida a terapêutica fibrinolítica, após episódio de paragem cardiorrespiratória. Na angiotomografia de tórax feita posteriormente para confirmac¸ão diagnóstica demonstra-se a presenc¸a não só de trombos no nível da artéria pulmonar, mas também de dissec¸ão da aorta Stanford B, tendo-se optado pela manutenc¸ão de anticoagulac¸ão terapêutica e a doente evoluído de forma favorável.The authors describe a case of a patient admitted with a pre-syncopal episode and precordial discomfort, and whose cardiac ultrasound performed in the Emergency Room was suggestive of Pulmonary Embolism. The patient was submitted to fibrinolytic therapy after cardiac arrest. The computerized tomography done after this episode not only confirmed the presence of pulmonary embolism but had also shown a Stanford Type B Aortic Dissection. The option was to maintain the therapeutic anticoagulation, having the patient evolved favourably.info:eu-repo/semantics/publishedVersio

Advances in Membrane-Bound Catechol-O-Methyltransferase Stability Achieved Using a New Ionic Liquid-Based Storage Formulation

Funding: The authors acknowledge the support from FEDER funds through the POCI—COMPETE 2020—Operational Program Competitiveness and Internationalization in Axis I—Strengthening research, technological development, and innovation (Project POCI-01-0145-FEDER-007491) and National Funds (Project UID/Multi/00709/2013) LA/P/0006/2020, financed by national funds through the Portuguese Foundation for Science and Technology/MCTES (PIDDAC). This work was also supported by the Applied Molecular Biosciences Unit UCIBIO (UIDB/04378/2020 and UIDP/04378/2020) and the Associate Laboratory Institute for Health and Bioeconomy—i4HB (project LA/P/0140/2020) which are financed by National Funds from FCT/MCTES. Researchers also acknowledge funding by FEDER through COMPETE 2020—Programa Operacional Compet-itividade e Internacionalização (POCI), Augusto Q. Pedro research contract CEEC-IND/02599/2020 under the Scientific Stimulus Publisher Copyright: © 2022 by the authors. Licensee MDPI, Basel, Switzerland.Membrane-bound catechol-O-methyltransferase (MBCOMT), present in the brain and involved in the main pathway of the catechol neurotransmitter deactivation, is linked to several types of human dementia, which are relevant pharmacological targets for new potent and nontoxic inhibitors that have been developed, particularly for Parkinson’s disease treatment. However, the inexistence of an MBCOMT 3D-structure presents a blockage in new drugs’ design and clinical studies due to its instability. The enzyme has a clear tendency to lose its biological activity in a short period of time. To avoid the enzyme sequestering into a non-native state during the downstream processing, a multi-component buffer plays a major role, with the addition of additives such as cysteine, glycerol, and trehalose showing promising results towards minimizing hMBCOMT damage and enhancing its stability. In addition, ionic liquids, due to their virtually unlimited choices for cation/anion paring, are potential protein stabilizers for the process and storage buffers. Screening experiments were designed to evaluate the effect of distinct cation/anion ILs interaction in hMBCOMT enzymatic activity. The ionic liquids: choline glutamate [Ch][Glu], choline dihydrogen phosphate ([Ch][DHP]), choline chloride ([Ch]Cl), 1-dodecyl-3-methylimidazolium chloride ([C12mim]Cl), and 1-butyl-3-methylimidazolium chloride ([C4mim]Cl) were supplemented to hMBCOMT lysates in a concentration from 5 to 500 mM. A major potential stabilizing effect was obtained using [Ch][DHP] (10 and 50 mM). From the DoE 146% of hMBCOMT activity recovery was obtained with [Ch][DHP] optimal conditions (7.5 mM) at −80◦ C during 32.4 h. These results are of crucial importance for further drug development once the enzyme can be stabilized for longer periods of time.publishersversionpublishe

MUVTIME: a Multivariate time series visualizer for behavioral science

As behavioral science becomes progressively more data driven, the need is increasing for appropriate tools for visual exploration and analysis of large datasets, often formed by multivariate time series. This paper describes MUVTIME, a multimodal time series visualization tool, developed in Matlab that allows a user to load a time series collection (a multivariate time series dataset) and an associated video. The user can plot several time series on MUVTIME and use one of them to do brushing on the displayed data, i.e. select a time range dynamically and have it updated on the display. The tool also features a categorical visualization of two binary time series that works as a high-level descriptor of the coordination between two interacting partners. The paper reports the successful use of MUVTIME under the scope of project TURNTAKE, which was intended to contribute to the improvement of human-robot interaction systems by studying turn- taking dynamics (role interchange) in parent-child dyads during joint action.Marie Curie International Incoming Fellowship PIIF-GA-2011- 301155; Portuguese Foundation for Science and Technology (FCT) project PTDC/PSI- PCO/121494/2010; AFP was also partially funded by the FCT project (IF/00217/2013)This research was supported by: Marie Curie International Incoming Fellowship PIIF-GA-2011301155; Portuguese Foundation for Science and Technology (FCT) Strategic program FCT UID/EEA/00066/2013; FCT project PTDC/PSIPCO/121494/2010. AFP was also partially funded by the FCT project (IF/00217/2013). REFERENCE

Visual-vestibular and postural analysis of motion sickness, panic, and acrophobia

Trigger motion sickness and can also have a role in some anxiety disorders. We explore a method to detect individual sensitivity to visual-vestibular unusual patterns, which can signal a vulnerability to develop motion sickness and possibly anxiety disorders such as a fear of heights and panic. 65 undergraduate students were recruited for the purposes of this study as voluntary participants (44 females); average age 21.65 years (SD=2.84) with normal or corrected to normal vision, without vestibular or postural deficiencies. Panic was assessed with the Albany Panic and Phobia Questionnaire, Motion Sickness with the Motion Sickness Susceptibility Questionnaire and Acrophobia was assessed by means of the Acrophobia Questionnaire. The Sharpened Romberg Test was used to test participant’s postural balance. The Rod and Frame Test (RFT) measures the participant’s ability to align a rod to the vertical within a titled frame providing a measure of error in the perception of verticality by degrees. This test was changed to measure the error offered when a participant’s head was tilted, and to trace the error caused by manipulating the vestibular system input. The main findings show only motion sickness to be correlated with significant errors while performing a visual-vestibular challenging situation, and fear of heights is the only anxiety disorder connected with postural stability, although all disorders (fear of heights, panic and motion sickness) are correlated between each other in the self- report questionnaires. All disorders are correlated to each other in the surveys, and might have some common visual-vestibular origin, in theory. The rod and frame test was exclusively correlated with motion sickness whereas the postural stability test only displayed sensibility to acrophobia. Panic disorder was correlated to neither the RFT nor the Romberg. Although this method was initially employed to increase sensibility in order to detect anxiety disorders, it ended up showing its value in the detection of motion sickness.National funds and co-financed by FEDER through COMPETE2020 under the PT2020 Partnership Agreement (POCI-01-0145-FEDER-007653). FCT/3599-PPCDT/121494/PTGrant IF/00217/ 2013info:eu-repo/semantics/publishedVersio

Bioengineered cell culture systems of central nervous system injury and disease

Cell culture systems, either 2D or explant based, have been pivotal to better understand the pathophysiology of several central nervous system (CNS) disorders. Recently, bioengineered cell culture systems have been proposed as an alternative to the traditional setups. These innovative systems often combine different cell populations in 3D environments that more closely recapitulate the different niches that exist within the developing or adult CNS. Given the importance of such systems for the future of CNS-related research, we discuss here the most recent advances in the field, particularly those dealing with neurodegeneration, neurodevelopmental disorders, and trauma.Financial support is acknowledged from Prémios Santa Casa Neurociências – Prize Melo e Castro for Spinal Cord Injury Research; Portuguese Foundation for Science and Technology [Doctoral fellowship (SFRH/BD/103075/2014) to E.D.G.; IF Development Grant to A.J.S.; Starting Grant to F. Marques; PostDoctoral fellowship SFRH/BPD/97701/2013 to N.A.S.]; this work was co-funded by Programa Operacional Regional do Norte (ON.2 – O Novo Norte), ao abrigo do Quadro de Referência Estratégico Nacional (QREN), através do Fundo Europeu de Desenvolvimento Regional (FEDER).info:eu-repo/semantics/publishedVersio

Expeditious modelling of virtual urban environments with geospatial L-systems

This paper presents Geospatial L-systems, a new extension of L-systems that incorporates geospatial awareness, and shows an application of this new tool in the expeditious modelling of urban environments, integrated with a modelling system with interoperable access to data sources. L-systems have been used in Computer Graphics for the modelling of plants, and in a few experiments to model urban environments. However, the lack of geospatial awareness is a limitation and in spite of some developments like open l-systems introduced the ability to communicate with the environment, there was a need for more flexibility. A new modelling system, named XL3D, generates virtual urban environments automatically from a XL3D document with a modelling specification. This modelling system accesses data sources in a interoperable way and the modelling processes are based on L-systems. The integration of geospatial L-systems with the XL3D modelling system has increased its potential for automation and improved the potential to generate virtual urban environments with a higher level of detail and visual fidelity, with a lower level of complexity of the modelling processes. These facts are shown in a case study where a virtual urban environment taken from an area in the Porto downtown is generated by this solution

Serious pervasive games

Serious Pervasive Games extend themagic circle (Huizinga, 1938) to the players’ context and surrounding environment. The blend of both physical and fictive game worlds provides a push in player engagement and promotes situated learning approaches. Space and time, as well as social context, acquire a more meaningful impact on the gameplay. From pervasive learning towards science communication with location-based games, this article presents research and case studies that exemplify their benefits and related problems. Pervasive learning can be defined as “learning at the speed of need through formal, informal and social learning modalities” (Pontefract, 2013). The first case study—the BEACONING project—aims to contextualize the teaching and learning process, connecting it with problem-based game mechanics within STEM. The main goal of this project is to provide the missing connection between STEM subjects and real-world interactions and applications. The pedagogical foundation is supported on problem-based learning (PBL), in which active learning is in the center, and learners have to work with different tools and resources in order to solve problems (quests). Teachers create, facilitate, and assess pervasive and gamified learning activities (missions). Furthermore, these quests are gamified in order to provide non-linear game plots. In a second case study, we demonstrate and evaluate how natural heritage can benefit from pervasive games. This study is based on a set of location-based games for an existing natural park, which have been developed in order to provide enhanced experiences, as well as additional information about some species that are more difficult to observe or that are seasonal. Throughout the research and development of these projects, we have encountered and identified several problems, of different nature, present in pervasive games.This work was financed by the ERDF - European Regional Development Fund through the Operational Programme for Competitiveness and Internationalisation - COMPETE 2020 Programme and by National Funds through the Portuguese funding agency, FCT - Fundação para a Ciência e a Tecnologia within project POCI-01-0145-FEDER-030740 - PTDC/CCICOM/30740/2017. Part of this work has also been supported by the European Union’s Horizon 2020 - The EU Framework Programme for Research and Innovation 2014–2020, under grant agreement No. 687676. We would also acknowledge the research grant from the Operation NORTE-08-5369-FSE-000049 supported by Norte Portugal Regional Operational Programme (NORTE 2020), under the PORTUGAL 2020 Partnership Agreement, through the European Social Fund (ESF), and also the FCT-Austin grant Ref. PD/BD/142893/2018.info:eu-repo/semantics/publishedVersio